Per Ump Scorecards, going into today, the O's were the fifth-most negatively impacted team in the MLB.
And that's going by their stats, which weigh missed pitches by impact to win percentage. If you were to instead measure by taking each time a bad call extended the opponent's hitting during an inning, treating it as an "umpire error" and making everything that followed umpire-charged runs following the unearned run rules, it'd likely be even worse.