Nah. Not if you are solo. Call an Uber/Lyft. Hell, I'll pay for you one myself.
If you are walking ALONE and on the path that I think you would, you are only fine until you pass the backside of M&T. From what I remember, you would be walking under 295 then up a huge stair case and back down. That area is not well lit, very deserted, etc. You would be a walking mark for someone to rob.
If you are with some people, that's your call. A crowd of people could be going to the casino and you would probably be OK.
IMO its not worth it. Walking the streets of south Baltimore at night and solo....is just not smart.