Based on those splits I'd go:
RHP) 1B- O'Hearn, 2B- Frazier, SS-Henderson, 3B- Urias
LHP) 1B- Mountcastle, 2B- Ortiz, SS-Mateo, 3B- Urias
Santander would be my DH for that one-game scenario because Rutschman is definitely catching.
Ortiz and Urias could be swapped at 2B/3B but I'm going with the best defenders.