I disagree, Frobingo, although I do see your points.
The steroid era has come and gone (allegedly) and if it wasn't done by someone during that time, I have a hard time thinking it'll be done now.
The other thing is that Eutaw Street and the Warehouse both sit above the playing field at Camden Yards by a pretty decent amount. If the Warehouse was level to the playing field I'd be more inclined to agree that it can be done...and I think it'd be done already.
The "true distance" that the ball has to go as a result is really farther than the 450+ feet or so. I'm not sure how to do the math on that, nor do I really care as I hate math. But I'm sure someone here who's adept with numbers can figure out the extra distance that you have to account for due to the playing level being below the Warehouse.
Then try to see if any homers hit in the Statcast Era would have hit it. I'd be curious to see.
Anyway, the best chance to hit it, as you noted, is directly down the line. That's hard to do because if a batter pulls it, it'll tend to hook a little.