On one hand, it's always a bad thing when a pitcher has to get a 4th out, either because of an error or an umpire's mistake. On the other hand, a pitcher still has to execute and can't serve up a meatball.
That being said, that was probably the most impactful non-strike call I can remember this year, maybe a few years.
EDIT: From Melewski - "Sometimes the strike call you don't get leads to the fastball you throw that leaves the ballpark."